https://doi.org/10.1093/toxsci/kfm080, Beckstead MJ, Weiner JL, Eger EI et al (2000) Glycine and gamma-aminobutyric acid(A) receptor function is enhanced by inhaled drugs of abuse. Exposure to higher concentrations leads to clouding or loss of consciousness. https://doi.org/10.3389/fpsyg.2015.01158, PubMed Top answers from doctors based on your search: Disclaimer. © 2020 Springer Nature Switzerland AG. Toxicol Sci 98:159–166. Another complication in the literature on the acute effects of toluene is that the course of effects or the effective dose may differ depending on the behavioral test used. Here we report the effects of a toluene-ace-tone mixture. Toluene was introduced through a port and volatilized by a hot-plate. Neurotoxicology 30(6):1223–1232, Horváth M, Frantík E, Krekule P (1981) Diazepam impairs alertness and potentiates the similar effect of toluene. Thus we examined the memory function‐related gene expressions in the mice hippocampus 24 h after toluene administration. J Physiol 545:153–167. In the present study, toluene (300 mg kg −1 , i.p.) Although abnormal neurological signs were observed after toluene exposure, these disappeared within 24 h and no toluene-related toxicological effects were observed in the liver, lungs, or kidneys. The evidence suggests that inhaling toluene at 100 ppmover seven hours can cause slight impair-ments in vigilance, manual dexterity, and, perhaps, in visual memory.Theobjective ofthe present study was to determine whether these acute effects would https://doi.org/10.1016/j.ntt.2010.02.002, Chen R (2000) Studies of human motor physiology with transcranial magnetic stimulation. Archives of Toxicology Mentioning: 6 - Acute effects of a single i.p. https://doi.org/10.1113/jphysiol.1997.sp021905, Nissen MJ, Bullemer P (1987) Attentional requirements of learning: evidence from performance measures. Act Nerv Super (Praha) 23:177–179, ICIS (2007) Toluene uses and market data, 2007. https://www.icis.com/resources/news/2007/11/07/9076550/toluene-uses-and-market-data/, Ilić TV, Meintzschel F, Cleff U et al (2002) Short-interval paired-pulse inhibition and facilitation of human motor cortex: the dimension of stimulus intensity. Overall, no clear pattern of … In humans a number of subjective sensations such as headache, dizziness, feeling of intoxication, irritation and sleepiness and decreases in acute neurobehavioural performance are seen following acute exposure = 75 ppm.
Toluene products are abused via inhalation for their intoxicating effects. Toxicology 265:34–40. Chronic exposure due to solvent abuse can result in permanent neuropsychiatric effects. https://doi.org/10.1016/j.neuroscience.2004.08.040, Bale AS, Jackson MD, Krantz QT et al (2007) Evaluating the NMDA-glutamate receptor as a site of action for toluene, in vivo. Work Environ Health 9:131–139, CAS These behavioral flexibility deficits observed suggests dysfunctional medial prefrontal cortex (mPFC) activity. Behavioral toxicity of toluene has been assessed in mice. A significant interaction was observed between toluene and block for HR, which could be caused by increased arousal of the toluene-naïve participants in the first block. Exp Brain Res 135:455–461. Toluene is a well-known neurotoxic organic solvent and a major component of many industrial and commercial products such as adhesives, paint thinners and gasoline. The purpose of this study was to investigate the effects of acute exposure to toluene on cortical excitability, plasticity, and implicit motor learning in healthy volunteers. Echeverria, Diana. endstream
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